New pill `may have life-changing effects
on those suffering from obesity`
In a new study, scientists have defined the
structure of a key part of the human obesity
receptor that is an essential factor in the
regulation of body fat and could help provide
new treatments for the complications of
obesity and anorexia.
This major advance in research, conducted by
medical researchers from the University of
Sheffield, will greatly enhance the ability to
generate drugs that can both block and
stimulate the receptor for the obesity hormone leptin.
This could have life-changing effects on people suffering from the complications of obesity and malnutrition. Researchers have solved the challenging crystal structure of the leptin-binding domain of the obesity receptor using state of the art X-ray crystallography, helping them to work
out how to block or stimulate the receptor.
Leptin, the obesity hormone, is produced by fat and excess leptin predisposes overweight
people to conditions such as multiple sclerosis, cancer and heart disease whilst a deficiency in leptin, as occurs in malnutrition, results in infertility and immunodeficiency.
Blocking the receptor, and therefore the
excessive actions of leptin, could prevent the
complications of obesity and stimulating the
receptor may improve fertility and the immune response.
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New pill `may have life-changing effects on those suffering from obesity` - Sci/Tech - DNA
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